STXBP1 antibody (Middle Region)
Quick Overview for STXBP1 antibody (Middle Region) (ABIN2792301)
Target
See all STXBP1 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- Middle Region
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Sequence
- TRSSASFSTT AVSARYGHWH KNKAPGEYRS GPRLIIFILG GVSLNEMRCA
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Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Rabbit: 100%, Zebrafish: 86%
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Characteristics
- This is a rabbit polyclonal antibody against STXBP1. It was validated on Western Blot using a cell lysate as a positive control.
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Purification
- Affinity Purified
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Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human STXBP1
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Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
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Comment
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Antigen size: 594 AA
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- STXBP1 (Syntaxin Binding Protein 1 (STXBP1))
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Alternative Name
- STXBP1
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Background
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STXBP1 belongs to the STXBP/unc-18/SEC1 family. It may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. The protein is essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. It can interact with syntaxins 1, 2, and 3 but not syntaxin 4.
Alias Symbols: MUNC18-1, UNC18, hUNC18, rbSec1, P67, NSEC1, RBSEC1
Protein Interaction Partner: STX19, SYTL4, TRIM38, STX11, STX1A, APBA2, APBA1, UBC, SQSTM1, DYT10, IQCB1, Htt, KCTD3, APP, STX3, STX2, USO1, DOC2B, DOC2A, CDK5R1, PLD2, PLD1, STX1B, PRKCG, PRKCB, PRKCA, NEFM, NEFH, MAPT, CDK5, HGS, Stx5, Dlg4, STX4, TUBB2A, TUBA4A,
Protein Size: 594 -
Molecular Weight
- 67 kDa
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Gene ID
- 6812
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NCBI Accession
- NM_001032221, NP_001027392
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UniProt
- P61764
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Pathways
- Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
Target
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