SOX8 antibody (C-Term)

Catalog No. ABIN2792566

This Rabbit Polyclonal antibody specifically detects SOX8 in WB. It exhibits reactivity toward Human, Mouse, Rat, Guinea Pig, Cow, Dog and Horse.

Quick Overview for SOX8 antibody (C-Term) (ABIN2792566)

Target: SOX8 (SRY (Sex Determining Region Y)-Box 8 (SOX8))

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOX8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SOX8 Antibody

Binding Specificity: C-Term

Sequence: ASPTETGPPR PHIKTEQPSP GHYGDQPRGS PDYGSCSGQS SATPAAPAGP

Cross-Reactivity: Dog (Canine), Human, Mouse (Murine), Rat (Rattus)

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 85%, Horse: 92%, Human: 100%, Mouse: 78%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against SOX8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SOX8

Application Details

Application Notes: WB Suggested Anti-SOX8 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:12500
Positive Control: Hela cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 446 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SOX8

Target: SOX8 (SRY (Sex Determining Region Y)-Box 8 (SOX8))

Alternative Name: SOX8

Background: SOX8 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. It may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
Alias Symbols: MGC24837
Protein Interaction Partner: JAM2, PIDD1, NOD1, UBC, MMP1, SOX2, HOXC11, UTF1, PAX3, OLIG2, HHEX, POU3F3, TCF12, DLX5, SP1, NR5A1, JUN, POU5F1, EGR2, CEBPA,
Protein Size: 446

Molecular Weight: 47 kDa

Gene ID: 30812

NCBI Accession: NM_014587, NP_055402

UniProt: P57073

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development