ETV6 antibody (C-Term)

Catalog No. ABIN2792592

This Rabbit Polyclonal antibody specifically detects ETV6 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Horse, Rabbit and Guinea Pig.

Quick Overview for ETV6 antibody (C-Term) (ABIN2792592)

Target: ETV6 (Ets Variant 6 (ETV6))

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Dog, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ETV6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ETV6 Antibody

Binding Specificity: C-Term

Sequence: VSVSPPEEHA MPIGRIADCR LLWDYVYQLL SDSRYENFIR WEDKESKIFR

Cross-Reactivity: Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against ETV6. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ETV6

Application Details

Application Notes: WB Suggested Anti-ETV6 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 452 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ETV6

Target: ETV6 (Ets Variant 6 (ETV6))

Alternative Name: ETV6 / TEL1

Background: ETV6 (ETS-related protein Tel1, ETS translocation variant 6 , Tel) is an ETS family transcription factor. This protein contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: TEL, TEL/ABL
Protein Interaction Partner: AP1M1, WDYHV1, UBC, SUMO1, NEDD8, ETV6, SUMO2, PIN1, HDAC6, SOX2, TRAF3, SOCS3, SOCS1, PDGFRB, ELAVL1, UBE2I, NCOR1, SIN3A, HDAC3, L3MBTL1, SMURF1, HDAC9, KAT5, FLI1, IRF8, SKP1, FBXL6, GAB2, GRB2, CRKL, ACTA1,
Protein Size: 452

Molecular Weight: 53 kDa

Gene ID: 2120

NCBI Accession: NM_001987, NP_001978

UniProt: P41212