DP1 antibody (Middle Region)

Catalog No. ABIN2792630

The Rabbit Polyclonal anti-DP1 antibody has been validated for WB. It is suitable to detect DP1 in samples from Human, Mouse, Cow and Zebrafish (Danio rerio).

Quick Overview for DP1 antibody (Middle Region) (ABIN2792630)

Target: DP1 (TFDP1) (Transcription Factor Dp-1 (TFDP1))

Reactivity: Human, Mouse, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DP1 Antibody

Binding Specificity: Middle Region

Sequence: FSASDLTNGA DGMLATSSNG SQYSGSRVET PVSYVGEDDE EDDDFNENDE

Cross-Reactivity: Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)

Predicted Reactivity: Cow: 92%, Human: 100%, Mouse: 100%, Zebrafish: 84%

Characteristics: This is a rabbit polyclonal antibody against TFDP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TFDP1

Application Details

Application Notes: WB Suggested Anti-TFDP1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: COLO205 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 410 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DP1

Target: DP1 (TFDP1) (Transcription Factor Dp-1 (TFDP1))

Alternative Name: TFDP1

Background: The E2F transcription factor family regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors and may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells. The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors, see TFDP2 (MIM 602160).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DP1, DRTF1, Dp-1
Protein Interaction Partner: UBC, E2F6, E2F4, SIAH1, E2F3, E2F2, E2F1, CDK6, PRPF31, CDK2, CDK1, SOCS3, RB1, PCGF6, RYBP, YAF2, RNF2, ELAVL1, LIN9, LIN54, LIN37, RBL2, SERTAD2, NPDC1, E2F5, TP53, RBL1, CDK3, TP53BP1,
Protein Size: 410

Molecular Weight: 45 kDa

Gene ID: 7027

NCBI Accession: NM_007111, NP_009042

UniProt: Q14186

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases