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MECP2 antibody (pSer421)

Name: MECP2 antibody (pSer421)
SKU: ABIN2794307
Price: 443.9 USD
Availability: InStock

The Rabbit Polyclonal anti-MECP2 antibody has been validated for DB. It is suitable to detect MECP2 in samples from Human.

Catalog No. ABIN2794307

Quick Overview for MECP2 antibody (pSer421) (ABIN2794307)

Target

See all MECP2 Antibodies

MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reactivity

Human

Host

Rabbit

Clonality

Polyclonal

Conjugate

This MECP2 antibody is un-conjugated

Application

Dot Blot (DB)

Discover our top product MECP2 Primary Antibody

Binding Specificity
14

11

11

8

7

7

7

3

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
pSer421

Purpose

Rabbit Anti-Human Phospho-MeCP2(S421) Antibody

Immunogen

This MeCP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S421 of human MeCP2.

Isotype

Ig Fraction
anti-Methyl CpG Binding Protein 2 (MECP2) (AA 7-148) antibody
MECP2 Reactivity: Human WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 8H4A5B9 unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (pSer423) antibody
MECP2 Reactivity: Human, Rat WB, IHC (p) Host: Rabbit Polyclonal RB29261 unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 81-170) antibody
MECP2 Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 1B11 unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 1-100) antibody
MECP2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 400-428) antibody
MECP2 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB25959 unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 1-486) antibody
MECP2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (C-Term) antibody
MECP2 Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 58-87), (N-Term) antibody
MECP2 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB27934 unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (AA 1-100) antibody
MECP2 Reactivity: Human IF Host: Rabbit Polyclonal unconjugated

anti-Methyl CpG Binding Protein 2 (MECP2) (N-Term) antibody
MECP2 Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated

Application Notes

Dot Blot
Recommended Dilutions
DB: 1:500
Dot blot analysis of anti-Phospho-MeCP2-S421 Pab on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 μg per ml.

Restrictions

For Research Use only
Format

Liquid

Concentration

0.350 mg/mL

Storage

4 °C,-20 °C

Storage Comment

2-8°C (short-term), -20°C (long-term)
Target

MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Alternative Name

MeCP2

Background

Target Description: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Gene Symbol: MECP2

Molecular Weight

52441 Da

Gene ID

4204

UniProt

P51608

Pathways

Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane