P-Glycoprotein antibody (Center)

Catalog No. ABIN2794800

Product Details anti-P-Glycoprotein Antibody

Target: P-Glycoprotein

Binding Specificity: AA 647-677, Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P-Glycoprotein antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit Anti-Human P-Glycoprotein (ABCB1) (Center) Antibody

Immunogen: This P-Glycoprotein (ABCB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-677 amino acids from the Central region of human P-Glycoprotein (ABCB1).

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000ABCB1 Antibody (L661) .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2.000 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for P-Glycoprotein

Target: P-Glycoprotein

Abstract: P-Glycoprotein Products

Synonyms: ABC20 antibody, CD243 antibody, CLCS antibody, GP170 antibody, MDR1 antibody, P-GP antibody, PGY1 antibody, Abcb1 antibody, Mdr1a antibody, ABCB1 antibody, ABCB4 antibody, CMDR1 antibody, xemdr antibody, ATP binding cassette subfamily B member 1 antibody, ATP binding cassette subfamily B member 1A antibody, ATP binding cassette subfamily B member 1 L homeolog antibody, ABCB1 antibody, Abcb1a antibody, abcb1.L antibody

Background:

Target Description: The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene Symbol: ABCB1

Molecular Weight: 141479 Da

Gene ID: 5243

UniProt: P08183