APC antibody (Center) (APC)

Catalog No. ABIN2795685

This anti-APC antibody is a Rabbit Polyclonal antibody detecting APC in WB. Suitable for Mouse.

Quick Overview for APC antibody (Center) (APC) (ABIN2795685)

Target: APC (Adenomatous Polyposis Coli (APC))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APC antibody is conjugated to APC

Application: Western Blotting (WB)

Product Details anti-APC Antibody (APC)

Binding Specificity: AA 1148-1176, Center

Purpose: Rabbit Anti-Mouse APC (Center) Antibody

Immunogen: This APC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1148-1176 amino acids from the Central region of human APC.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000APC Antibody (Center).

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for APC

Target: APC (Adenomatous Polyposis Coli (APC))

Alternative Name: APC

Background:

Target Description: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Gene Symbol: APC

Molecular Weight: 311646 Da

Gene ID: 324

UniProt: P25054

Pathways: WNT Signaling, Stem Cell Maintenance, Cell-Cell Junction Organization