GNAS antibody (C-Term)

Catalog No. ABIN2798020

This Rabbit Polyclonal antibody specifically detects GNAS in WB, IHC, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for GNAS antibody (C-Term) (ABIN2798020)

Target: GNAS (GNAS Complex Locus (GNAS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNAS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-GNAS Antibody

Binding Specificity: AA 287-315, C-Term

Purpose: Rabbit Anti-Human GNAS (C-term) Antibody

Immunogen: This GNAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human GNAS.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50, IF: 1:10-50, FC: 1:10-50Western blot analysis of GNAS (arrow) using rabbit polyclonal GNAS Antibody (C-term) .FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.420 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for GNAS

Target: GNAS (GNAS Complex Locus (GNAS))

Alternative Name: GNAS

Background:

Target Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

UniProt: Q5FWY2

Pathways: Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis