TERT antibody (Center)

Catalog No. ABIN2798432

The Rabbit Polyclonal anti-TERT antibody has been validated for WB, FACS and IF. It is suitable to detect TERT in samples from Human.

Quick Overview for TERT antibody (Center) (ABIN2798432)

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TERT antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-TERT Antibody

Binding Specificity: AA 627-656, Center

Purpose: Rabbit Anti-Human TERT (Center) Antibody

Immunogen: This TERT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 627-656 amino acids from the Central region of human TERT.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot, Flow Cytometry, Immunofluorescence
Recommended Dilutions
WB: 1:1000, FC: 1:10-50, IF: 1:10-50Western blot analysis of anti-TERT Antibody (Center) (RB14069) in Jurkat cell line lysates (35 μg/lane). TERT(arrow) was detected using the purified Pab.TERT Antibody (Center) . TERT immunoreactivity is localized to Nucleus significantly and Cytoplasm weakly.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2.0 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Alternative Name: TERT

Background:

Target Description: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.

Gene Symbol: TERT

Molecular Weight: 126997 Da

Gene ID: 7015

UniProt: O14746

Pathways: Telomere Maintenance