PITX2 antibody (C-Term)

Catalog No. ABIN2798528

The Rabbit Polyclonal anti-PITX2 antibody has been validated for WB and IF. It is suitable to detect PITX2 in samples from Human.

Quick Overview for PITX2 antibody (C-Term) (ABIN2798528)

Target: PITX2 (Paired-Like Homeodomain 2 (PITX2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PITX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PITX2 Antibody

Binding Specificity: AA 122-151, C-Term

Purpose: Rabbit Anti-Human PITX2 (C-term) Antibody

Immunogen: This PITX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids from the C-terminal region of human PITX2.

Isotype: Ig Fraction

Application Details

Application Notes: Immunofluorescence, Western Blot
Recommended Dilutions
IF: 1:10-50, WB: 1:1000Fluorescent image of Hela cell stained with PITX2 Antibody (C-term) was detected using the purified Pab.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.430 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for PITX2

Target: PITX2 (Paired-Like Homeodomain 2 (PITX2))

Alternative Name: PITX2

Background:

Target Description: Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

Gene Symbol: PITX2

Molecular Weight: 35370 Da

Gene ID: 5308

UniProt: Q99697

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development