PRDM6 antibody (N-Term)

Catalog No. ABIN2798584

This Rabbit Polyclonal antibody specifically detects PRDM6 in WB. It exhibits reactivity toward Human.

Quick Overview for PRDM6 antibody (N-Term) (ABIN2798584)

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRDM6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PRDM6 Antibody

Binding Specificity: AA 44-72, N-Term

Purpose: Rabbit Anti-Human PRDM6 (N-term) Antibody

Immunogen: This PRDM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human PRDM6.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000PRDM6 Antibody (N-term) .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.350 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for PRDM6

Target: PRDM6 (PR Domain Containing 6 (PRDM6))

Alternative Name: PRDM6

Background:

Target Description: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (By similarity).

Gene Symbol: PRDM6

Molecular Weight: 64452 Da

Gene ID: 93166

UniProt: Q9NQX0

Pathways: Regulation of Muscle Cell Differentiation