Chiffon antibody (C-Term)
Quick Overview for Chiffon antibody (C-Term) (ABIN2798594)
Target
Reactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 476-504, C-Term
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Purpose
- Rabbit Anti-Human CHFR (C-term) Antibody
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Immunogen
- This CHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-504 amino acids from the C-terminal region of human CHFR.
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Isotype
- Ig Fraction
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anti-Chiffon (CHIF) (AA 476-504), (C-Term) antibody
CHIF Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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Application Notes
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Western Blot
Recommended Dilutions
WB: 1:1000CHFR Antibody (C-term) . -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.5 mg/mL
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Storage
- 4 °C,-20 °C
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Storage Comment
- 2-8°C (short-term), -20°C (long-term)
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- Chiffon (CHIF)
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Alternative Name
- CHF
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Background
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Target Description: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Gene Symbol: CHFR
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Molecular Weight
- 73386 Da
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Gene ID
- 55743
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UniProt
- Q96EP1
Target
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