BAG4 antibody (C-Term)

Catalog No. ABIN2799014

The Rabbit Polyclonal anti-BAG4 antibody has been validated for WB. It is suitable to detect BAG4 in samples from Human.

Quick Overview for BAG4 antibody (C-Term) (ABIN2799014)

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAG4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BAG4 Antibody

Binding Specificity: AA 381-409, C-Term

Purpose: Rabbit Anti-Human BAG4 (C-term) Antibody

Immunogen: This BAG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-409 amino acids from the C-terminal region of human BAG4.

Isotype: Ig Fraction

Application Details

Application Notes: Western Blot
Recommended Dilutions
WB: 1:1000BAG4 Antibody (C-term) .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C (short-term), -20°C (long-term)

Target Details for BAG4

Target: BAG4 (BCL2-Associated Athanogene 4 (BAG4))

Alternative Name: BAG4

Background:

Target Description: BAG4 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.

Gene Symbol: BAG4

Molecular Weight: 49594 Da

Gene ID: 9530

UniProt: O95429

Pathways: Regulation of Actin Filament Polymerization