Metabotropic Glutamate Receptor 6 antibody

Catalog No. ABIN1944817

This Rabbit Polyclonal antibody specifically detects Metabotropic Glutamate Receptor 6 in WB and IHC. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for Metabotropic Glutamate Receptor 6 antibody (ABIN1944817)

Target: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Metabotropic Glutamate Receptor 6 Antibody

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000. IHC: 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-Metabotropic Glutamate Receptor 6 antibody (ABIN1944817)

Devi, Markandeya, Maddodi, Dhingra, Vardi, Balijepalli, Setaluri: "Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes." in: Pigment cell & melanoma research, Vol. 26, Issue 3, pp. 348-56, (2013) (PubMed).

Dryja, McGee, Berson, Fishman, Sandberg, Alexander, Derlacki, Rajagopalan: "Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 13, pp. 4884-9, (2005) (PubMed).

Hashimoto, Inazawa, Okamoto, Tagawa, Bessho, Honda, Nakanishi: "The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6." in: The European journal of neuroscience, Vol. 9, Issue 6, pp. 1226-35, (1997) (PubMed).

Target Details for Metabotropic Glutamate Receptor 6

Target: Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

Alternative Name: mGluR6

Background: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.

Molecular Weight: 95468 Da

Gene ID: 2916

UniProt: O15303