MARK2 antibody (pSer595) (AbBy Fluor® 594)

Catalog No. ABIN2804020

This anti-MARK2 antibody is a Rabbit Polyclonal antibody detecting MARK2 in WB and IF (p). Suitable for Human, Mouse and Rat.

Quick Overview for MARK2 antibody (pSer595) (AbBy Fluor® 594) (ABIN2804020)

Target: MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARK2 antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-MARK2 Antibody (AbBy Fluor® 594)

Binding Specificity: pSer595

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human MARK2 around the phosphorylation site of Ser595

Isotype: IgG

Application Details

Application Notes: IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MARK2

Target: MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))

Alternative Name: MARK2

Background:

Synonyms: ELKL mot kinase 1, MARK2phospho S595, ELKL mot kinase, EMK-1, EMK1, MAP/microtubule affinity regulating kinase 2, MAP/microtubule affinity-regulating kinase 2, Mark2, MARK2_HUMAN, PAR1 homolog, Serine/threonine protein kinase MARK2, Serine/threonine-protein kinase MARK2.

Background: MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule.stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. Human MARK2 was shown to be encoded by a single mRNA ubiquitously expressed. This transcription variant includes the alternative exon in the coding region and therefore codes for a longer protein. Multiple splice variants exist for this protein.

Gene ID: 2011

UniProt: Q7KZI7

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection