Neurofibromin 1 antibody (pSer2515) (AbBy Fluor® 594)

Catalog No. ABIN2804599

This anti-Neurofibromin 1 antibody is a Rabbit Polyclonal antibody detecting Neurofibromin 1 in IF (cc) and IF (p). Suitable for Human and Mouse.

Quick Overview for Neurofibromin 1 antibody (pSer2515) (AbBy Fluor® 594) (ABIN2804599)

Target: Neurofibromin 1 (NF1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurofibromin 1 antibody is conjugated to AbBy Fluor® 594

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Neurofibromin 1 Antibody (AbBy Fluor® 594)

Binding Specificity: pSer2515

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human NF1 around the phosphorylation site of Ser2515

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Neurofibromin 1

Target: Neurofibromin 1 (NF1)

Alternative Name: NF1

Background:

Synonyms: NF1phospho S2515, p-NF1S2515, DKFZp686J1293, FLJ21220, Neurofibromatosis Noonan syndrome, Neurofibromatosis related protein NF 1, Neurofibromatosis related protein NF1, neurofibromatosis type I, Neurofibromatosis-related protein NF-1, Neurofibromin 1, Neurofibromin truncated, Neurofibromin1, NF 1, NF, NF1, NF1_HUMAN, NFNS, Type 1 Neurofibromatosis, von Recklinghausen disease neurofibromin, von Recklinghausen disease related protein VRNF, VRNF, WATS, Watson disease related protein WSS, Watson syndrome, WSS.

Background: Neurofibromin is a product of the tumor suppressor gene, Neurofibromatosis type I. Neurofibromin is known to have GTPase activity that modulates the ras pathway. The absence of or alteration of the neurofibromin protein may lead to Neurofibromatosis disease. This protein has not been purified, therefore, most of the information regarding this protein has been deduced from homology analysis of its gene sequence.

Gene ID: 4763

Pathways: cAMP Metabolic Process, Regulation of long-term Neuronal Synaptic Plasticity