STIL antibody (AbBy Fluor® 594)

Catalog No. ABIN2806728

This Rabbit Polyclonal antibody specifically detects STIL in WB and IF (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for STIL antibody (AbBy Fluor® 594) (ABIN2806728)

Target: STIL (SCL/TAL1 Interrupting Locus (STIL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STIL antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-STIL Antibody (AbBy Fluor® 594)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human STIL

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for STIL

Target: STIL (SCL/TAL1 Interrupting Locus (STIL))

Alternative Name: STIL

Background:

Synonyms: MCPH7, SCL interrupting locus protein, SCL-interrupting locus protein, SCL/TAL1 interrupting locus, SIL, STIL, STIL_HUMAN, TAL 1 interrupting locus protein, TAL-1-interrupting locus protein.

Background: TAL1 disruption at 1p32, a common rearrangement in the T-cell acute lymphoblastic leukemia, usually results in the formation of a SCL interrupting locus (SIL)-TAL1 fusion product. SIL is an immediate early gene whose expression is associated with cell proliferation. The Sil protein exhibits ubiquitous expression in hematopoietic cell lines and tissues. However, Sil protein levels remain tightly regulated during the cell cycle, achieving peak levels in mitosis and diminishing on transition to G1 phase. Overexpression of Sil in primary adenocarcinomas predicts metastatic spread, especially in lung tumors with increased mitotic activity.

Gene ID: 6491

Pathways: Tube Formation