TXN2 antibody (AA 101-166) (AbBy Fluor® 594)

Catalog No. ABIN2807004

This Rabbit Polyclonal antibody specifically detects TXN2 in WB, IF (cc) and IF (p). It exhibits reactivity toward Rat.

Quick Overview for TXN2 antibody (AA 101-166) (AbBy Fluor® 594) (ABIN2807004)

Target: TXN2 (Thioredoxin 2 (TXN2))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXN2 antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-TXN2 Antibody (AbBy Fluor® 594)

Binding Specificity: AA 101-166

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Thioredoxin 2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TXN2

Target: TXN2 (Thioredoxin 2 (TXN2))

Alternative Name: Thioredoxin 2

Background:

Synonyms: mitochondrial thioredoxin, MT-TRX, MTRX, thioredoxin 2 precursor, Thioredoxin mitochondrial, Thioredoxin2, TRX 2, TRX2, TXN 2, TXN2.

Background: Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1. Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

Gene ID: 25828

Pathways: Cell RedoxHomeostasis