RanBP3 antibody (AA 441-540) (Cy7)

Catalog No. ABIN2808019

The Rabbit Polyclonal anti-RanBP3 antibody has been validated for WB, IF (p) and IF (cc). It is suitable to detect RanBP3 in samples from Mouse and Rat.

Quick Overview for RanBP3 antibody (AA 441-540) (Cy7) (ABIN2808019)

Target: RanBP3 (RANBP3) (RAN Binding Protein 3 (RANBP3))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RanBP3 antibody is conjugated to Cy7

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-RanBP3 Antibody (Cy7)

Binding Specificity: AA 441-540

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RanBP3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RanBP3

Target: RanBP3 (RANBP3) (RAN Binding Protein 3 (RANBP3))

Alternative Name: RanBP3

Background:

Synonyms: Ran-binding protein 3, RanBP3

Background: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

Gene ID: 8498

UniProt: Q9H6Z4