RanBP3 antibody (AA 441-540) (HRP)

Catalog No. ABIN2808335

This anti-RanBP3 antibody is a Rabbit Polyclonal antibody detecting RanBP3 in WB, ELISA, IHC (p) and IHC (fro). Suitable for Mouse and Rat.

Quick Overview for RanBP3 antibody (AA 441-540) (HRP) (ABIN2808335)

Target: RanBP3 (RANBP3) (RAN Binding Protein 3 (RANBP3))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RanBP3 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-RanBP3 Antibody (HRP)

Binding Specificity: AA 441-540

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RanBP3

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RanBP3

Target: RanBP3 (RANBP3) (RAN Binding Protein 3 (RANBP3))

Alternative Name: RanBP3

Background:

Synonyms: Ran-binding protein 3, RanBP3

Background: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

Gene ID: 8498

UniProt: Q9H6Z4