APH1B antibody (AA 51-150) (AbBy Fluor® 594)

Catalog No. ABIN2809827

This Rabbit Polyclonal antibody specifically detects APH1B in WB, IF (cc) and IF (p). It exhibits reactivity toward Mouse.

Quick Overview for APH1B antibody (AA 51-150) (AbBy Fluor® 594) (ABIN2809827)

Target: APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APH1B antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-APH1B Antibody (AbBy Fluor® 594)

Binding Specificity: AA 51-150

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Aph-1b

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for APH1B

Target: APH1B (Aph1b) (Anterior Pharynx Defective 1 Homolog B (Aph1b))

Alternative Name: Aph-1b

Background:

Synonyms: PSFL, APH-1B, PRO1328, TAAV688, Gamma-secretase subunit APH-1B, Aph-1beta, Presenilin-stabilization factor-like, APH1B, UNQ688/PRO1328

Background: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.

Gene ID: 83464

UniProt: Q8WW43

Pathways: Notch Signaling, Neurotrophin Signaling Pathway