beta Catenin antibody (pThr41) (AbBy Fluor® 594)

Catalog No. ABIN2810281

The Rabbit Polyclonal anti-beta Catenin antibody has been validated for FACS, IF (cc) and IF (p). It is suitable to detect beta Catenin in samples from Human and Mouse.

Quick Overview for beta Catenin antibody (pThr41) (AbBy Fluor® 594) (ABIN2810281)

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta Catenin antibody is conjugated to AbBy Fluor® 594

Application: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-beta Catenin Antibody (AbBy Fluor® 594)

Binding Specificity: pThr41

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human beta Catenin around the phosphorylation site of Thr41

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for beta Catenin

Target: beta Catenin (CATNB) (Catenin, beta (CATNB))

Alternative Name: beta Catenin

Background:

Synonyms: beta Catenin phospho T41, beta Catenin phospho Thr41, p-beta Catenin T41, p-beta Catenin Thr41, p-beta Catenin phospho T41, p-beta Catenin phospho Thr41, beta-catenin, beta catenin, CTNNB1, CHBCAT, CTNNB1, CTNNB, PRO2286, Cadherin associated protein, Catenin cadherin associated protein, beta 1, 88 kDa, Catenin beta 1, Catenin beta-1, CATNB, CTNB1_HUMAN, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, b-catenin, OTTHUMP00000162082, OTTHUMP00000165222, OTTHUMP00000165223, OTTHUMP00000209288, OTTHUMP00000209289.

Background: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].

Gene ID: 1499

Pathways: Peptide Hormone Metabolism