TEFM antibody (AA 60-110) (AbBy Fluor® 594)

Catalog No. ABIN2810602

The Rabbit Polyclonal anti-TEFM antibody has been validated for WB and IF (p). It is suitable to detect TEFM in samples from Human, Mouse and Rat.

Quick Overview for TEFM antibody (AA 60-110) (AbBy Fluor® 594) (ABIN2810602)

Target: TEFM (Transcription Elongation Factor, Mitochondrial (TEFM))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEFM antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-TEFM Antibody (AbBy Fluor® 594)

Binding Specificity: AA 60-110

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C17orf42

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TEFM

Target: TEFM (Transcription Elongation Factor, Mitochondrial (TEFM))

Alternative Name: C17orf42

Background:

Synonyms: Chromosome 17 open reading frame 42, FLJ22729, Hypothetical protein LOC79736, MGC24674, UPF0629 protein C17orf42, TEFM_HUMAN, TEFM, transcription elongation factor, mitochondrial,

Background: C17orf42 is a 360 amino acid protein that exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

Gene ID: 79736

UniProt: Q96QE5