HAAO antibody (AA 101-200) (AbBy Fluor® 594)

Catalog No. ABIN2814123

This Rabbit Polyclonal antibody specifically detects HAAO in WB, IF (cc) and IF (p). It exhibits reactivity toward Mouse.

Quick Overview for HAAO antibody (AA 101-200) (AbBy Fluor® 594) (ABIN2814123)

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAAO antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-HAAO Antibody (AbBy Fluor® 594)

Binding Specificity: AA 101-200

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HAAO

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HAAO

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Alternative Name: HAAO

Background:

Synonyms: 3 HAO,3 hydroxyanthranilate 3 4 dioxygenase,3 hydroxyanthranilate dioxygenase,3 hydroxyanthranilate oxygenase,3 hydroxyanthranilic acid dioxygenase,3-HAO,3-hydroxyanthranilate 3,3-hydroxyanthranilate 3,4-dioxygenase,3-hydroxyanthranilate oxygenase,3-hydroxyanthranilic acid dioxygenase,3HAO_HUMAN,4-dioxygenase,haao,HAD,HAO.

Background: The 3-HAO family of proteins consists of intramolecular dioxygenases that contain non-heme ferrous iron. HAAO (3-hydroxyanthranilate 3,4-dioxygenase), also known as HAO or 3-HAO, is a 286 amino acid monomeric cytoplasmic protein that belongs to the 3-HAO family. Utilizing Fe2+ ions as a cofactor, HAAO participates in the formation of quinolinic acid (QUIN), and excitotoxin, by catalyzing the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. HAAO may play a role in disorders that are associated with varying levels of QUIN expression, and is widely expressed in peripheral organs, including kidney and liver. Existing as two alternatively spliced isoforms, the gene encoding HAAO maps to human chromosome 2p21 and mouse chromosome 17 E4.