FOXP3 antibody (Biotin)

Catalog No. ABIN2853612

The Rat Monoclonal anti-FOXP3 antibody is suitable to detect FOXP3 in samples from Mouse. It has been validated for FACS and IHC (fro).

Quick Overview for FOXP3 antibody (Biotin) (ABIN2853612)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This FOXP3 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: MF-14

Product Details anti-FOXP3 Antibody (Biotin)

Specificity: This antibody reacts with mouse Foxp3.

Purification: Protein G agarose

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: PBS containing 1 % BSA and 0.09 % NaN3

Storage: 4 °C

Storage Comment: Store at 2-8 °C.

Target Details for FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Alternative Name: FOXP3

Background: Forkhead-winged helix P3 (Foxp3), also known as Scurfin or JM2, is a 50-55 kDa transcription factor, originally identified as the gene defective in Scurfy mice. Scurfy mice and humans with similar mutations spontaneously develop autoimmune diseases (IPEX). Resent reports revealed that Foxp3 is expressed in CD4 + CD25 + regulatory T cells (Treg cells), and ectopic expression of Foxp3 in CD4 + Foxp3 - T cells induced a Treg-like phenotype in these cells. Importantly, these reports indicate that Foxp3 is a specific marker for Treg cells. Taken together, Foxp3 is believed to be a crucial regulator of the development and function of Treg cells.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin

Gene ID: 20371

NCBI Accession: NP_001186276

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation