DUSP14 antibody (C-Term)

Catalog No. ABIN2854481

The Rabbit Polyclonal anti-DUSP14 antibody has been validated for WB. It is suitable to detect DUSP14 in samples from Human.

Quick Overview for DUSP14 antibody (C-Term) (ABIN2854481)

Target: DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP14 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DUSP14 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to MKP-6 (dual specificity phosphatase 14)
MKP-6 antibody [C2C3], C-term

Purification: Affinity purified by Protein A.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human DUSP14. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: MKP-6 transfected 293T

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2 mg/mL

Buffer: 1XPBS ( pH 7), 40 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for DUSP14

Target: DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))

Alternative Name: dual specificity phosphatase 14

Background: In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80, MIM 112203) and B7-2 (CD86, MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2, MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4, MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.[supplied by OMIM]

Molecular Weight: 22 kDa

Gene ID: 11072

UniProt: O95147