ADRA2C antibody (C-Term)

Catalog No. ABIN2854717

This Rabbit Polyclonal antibody specifically detects ADRA2C in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for ADRA2C antibody (C-Term) (ABIN2854717)

Target: ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA2C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ADRA2C Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Characteristics: Rabbit Polyclonal antibody to alpha 2c Adrenergic Receptor (adrenergic, alpha-2C-, receptor)
alpha 2c Adrenergic Receptor antibody [C2C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human alpha 2c Adrenergic Receptor. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HeLa

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.62 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for ADRA2C

Target: ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))

Alternative Name: adrenoceptor alpha 2C

Background: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

Cellular Localization: Cell membrane

Molecular Weight: 50 kDa

Gene ID: 152

UniProt: P18825

Pathways: EGFR Signaling Pathway, cAMP Metabolic Process