RRM2 antibody (Regulatory Subunit)

Catalog No. ABIN2855573

The Rabbit Polyclonal anti-RRM2 antibody has been validated for WB, IF, IHC (p) and ICC. It is suitable to detect RRM2 in samples from Human. There is 1 publication available.

Quick Overview for RRM2 antibody (Regulatory Subunit) (ABIN2855573)

Target: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Grade: KO Validated

Product Details anti-RRM2 Antibody

Binding Specificity: Regulatory Subunit

Cross-Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio)

Characteristics: Rabbit Polyclonal antibody to RRM2 (ribonucleotide reductase M2)
RRM2 antibody [N1C1]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human RRM2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Validatio: KO/KD, Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.18 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-RRM2 antibody (ABIN2855573)

Su, Wu, Ko, Tsai, Tee, Chien, Chou, Lin, Low, Chou, Yang, Wang: "The expression of ribonucleotide reductase M2 in the carcinogenesis of uterine cervix and its relationship with clinicopathological characteristics and prognosis of cancer patients." in: PLoS ONE, Vol. 9, Issue 3, pp. e91644, (2015) (PubMed).

Target Details for RRM2

Target: RRM2 (Ribonucleotide Reductase M2 (RRM2))

Alternative Name: ribonucleotide reductase M2

Background: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion.

Cellular Localization: Cytoplasm

Molecular Weight: 45 kDa

Gene ID: 6241

UniProt: P31350

Pathways: Mitotic G1-G1/S Phases