PROC antibody

Catalog No. ABIN2856203

The Rabbit Polyclonal anti-PROC antibody has been validated for WB, ICC, IF and IHC (p). It is suitable to detect PROC in samples from Human.

Quick Overview for PROC antibody (ABIN2856203)

Target: PROC (Vitamin K-dependent protein C (PROC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PROC antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PROC Antibody

Cross-Reactivity: Human

Characteristics: Rabbit Polyclonal antibody to Protein C (vitamin K-dependent protein C)
Protein C antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Protein C. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for PROC

Target: PROC (Vitamin K-dependent protein C (PROC))

Alternative Name: protein C, inactivator of coagulation factors Va and VIIIa

Background: The PROC gene encodes protein C (EC 3.4.21.69), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, 'activated protein C' (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930, MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5, MIM 612309) and VIII (F8, see MIM 306700). Protein S (PROS1, MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C.[supplied by OMIM]

Molecular Weight: 52 kDa

Gene ID: 5624

UniProt: P04070