EVC2 antibody (C-Term)

Catalog No. ABIN2856532

This Rabbit Polyclonal antibody specifically detects EVC2 in WB, IF and ICC. It exhibits reactivity toward Human.

Quick Overview for EVC2 antibody (C-Term) (ABIN2856532)

Target: EVC2 (Ellis Van Creveld Syndrome 2 (EVC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EVC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-EVC2 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Mouse (Murine)

Cross-Reactivity (Details): Mouse (85 %)

Characteristics: Rabbit Polyclonal antibody to EVC2 (Ellis van Creveld syndrome 2)
EVC2 antibody [C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human EVC2. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference ICC/IF 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* Western blot1:500-1:3000*

Comment:

Positive Control: A431 , H1299 , HeLa , HepG2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for EVC2

Target: EVC2 (Ellis Van Creveld Syndrome 2 (EVC2))

Alternative Name: EVC2

Background: This gene encodes a protein that functions in bone formation and skeletal development. Mutations in this gene, as well as in a neighboring gene that lies in a head-to-head configuration, cause Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia that is also known as chondroectodermal dysplasia. Mutations in this gene also cause acrofacial dysostosis Weyers type, also referred to as Curry-Hall syndrome, a disease that combines limb and facial abnormalities. Alternative splicing results in multiple transcript variants.

Cellular Localization: Membrane, Multi-pass membrane protein

Molecular Weight: 148 kDa

Gene ID: 132884

Pathways: Hedgehog Signaling