OFD1 antibody (Center)

Catalog No. ABIN2856726

This anti-OFD1 antibody is a Rabbit Polyclonal antibody detecting OFD1 in WB and IHC (p). Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for OFD1 antibody (Center) (ABIN2856726)

Target: OFD1 (Oral-Facial-Digital Syndrome 1 (OFD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OFD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-OFD1 Antibody

Binding Specificity: Center

Characteristics: Rabbit Polyclonal antibody to OFD1 (oral-facial-digital syndrome 1)
OFD1 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human OFD1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:1000-1:10000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:1000-1:10000*

Comment:

Positive Control: Molt-4

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.96 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-OFD1 antibody (ABIN2856726)

Zhang, Li, Siu, Luo, Yu: "Distinct Roles of TRAPPC8 and TRAPPC12 in Ciliogenesis via Their Interactions With OFD1." in: Frontiers in cell and developmental biology, Vol. 8, pp. 148, (2020) (PubMed).

Target Details for OFD1

Target: OFD1 (Oral-Facial-Digital Syndrome 1 (OFD1))

Alternative Name: OFD1

Background: This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified, a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome. Alternatively spliced transcripts have been described for this gene but the biological validity of these transcripts has not been determined.

Cellular Localization: Cytoplasm , Centrosome

Molecular Weight: 117 kDa

Gene ID: 8481

Pathways: M Phase