SHROOM2 antibody (C-Term)

Catalog No. ABIN2857042

This Rabbit Polyclonal antibody specifically detects SHROOM2 in WB, IHC (p) and IHC (fro). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for SHROOM2 antibody (C-Term) (ABIN2857042)

Target: SHROOM2 (Shroom Family Member 2 (SHROOM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHROOM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SHROOM2 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human, Monkey, Mouse

Characteristics: Rabbit Polyclonal antibody to APXL (shroom family member 2)
APXL antibody [C3], C-term

Purification: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human APXL. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HepG2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-SHROOM2 antibody (ABIN2857042)

Badu-Nkansah, Lechler: "Proteomic analysis of desmosomes reveals novel components required for epidermal integrity." in: Molecular biology of the cell, Vol. 31, Issue 11, pp. 1140-1153, (2020) (PubMed).

Target Details for SHROOM2

Target: SHROOM2 (Shroom Family Member 2 (SHROOM2))

Alternative Name: shroom family member 2

Background: The protein encoded by this gene shares significant similarities with the apical protein from Xenopus laevis which is implicated in amiloride-sensitive sodium channel activity. This gene is a strong candidate gene for ocular albinism type 1 syndrome.

Cellular Localization: Apical cell membrane (By similarity) , Cell junction , tight junction (By similarity) , Cytoplasm , cytoskeleton (By similarity)

Molecular Weight: 176 kDa

Gene ID: 357

UniProt: Q13796

Pathways: Cell-Cell Junction Organization, Asymmetric Protein Localization