TdT antibody (N-Term) (FITC)

Catalog No. ABIN294481

This Mouse Monoclonal antibody specifically detects TdT in FACS. It exhibits reactivity toward Human.

Quick Overview for TdT antibody (N-Term) (FITC) (ABIN294481)

Target: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TdT antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Clone: HTdt-1-HTdt-2-HTdt-3

Product Details anti-TdT Antibody (FITC)

Binding Specificity: N-Term

Specificity: Is a mixture of 3 monoclonal antibodies specific for human terminal deoxynucleotidyl transferase (TdT). TdT is a DNA polymerase responsible for the catalysis of non-reversible addition of deoxynucleotides to the 3 end hydroxy groups of DNA. TdT levels are enhanced in all forms of acute lymphoblastic leukaemia (ALL) and in a significant number of chronic lymphoblastic leukaemia cases (CML). TdT is not expressed in the majority of myeloid leukemias, non-Hodgkins lymphomas or mature lymphoid leukemias.

Purification: Purified

Immunogen:

Type of Immunogen: Native protein

Application Details

Application Notes: Approved: Flo (1:1)

Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Membrane permeabilization is required for this application. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide, 1 % BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for TdT

Target: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Alternative Name: DNTT / TdT

Background: Name/Gene ID: DNTT

Synonyms: DNTT, DNA nucleotidylexotransferase, TDT, Terminal addition enzyme, Terminal transferase

Gene ID: 1791

Pathways: DNA Damage Repair