ANO1 antibody (AA 904-986)

Catalog No. ABIN2962568

The Mouse Monoclonal anti-ANO1 antibody (Clone DOG1-1) (ABIN2962568) specifically detects ANO1 in IHC. The antibody is reactive with Human samples.

Quick Overview for ANO1 antibody (AA 904-986) (ABIN2962568)

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ANO1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: DOG1-1

Product Details anti-ANO1 Antibody

Binding Specificity: AA 904-986

Specificity: Reacts with human DOG1.

Purification: Purified (protein G)

Immunogen: Synthetic peptide corresponding to aa 904-986 of human DOG1 (accession no. Q5XXA6).

Isotype: IgG1

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC(1 - 10 μg/mL)

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4

Handling Advice: Dilute in PBS or medium which is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: This antibody is stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Target Details for ANO1

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Alternative Name: DOG1

Background: DOG1 (Discovered on GIST1), also known as TMEM16A and ANO1, has emerged in recent years as a promising biomarker for gastrointestinal stromal tumors (GIST). It was originally discovered through microarray expression profiling analysis as a gene that is highly expressed in GIST, and subsequent immunohistochemical studies have shown its use in its diagnosis. DOG1 antibodies are more sensitive than KIT antibodies in detecting tumors of gastric origin, tumors with epithelioid morphology, and tumors harboring PDGFRA mutation. DOG1 immunoreactivity is rarely observed in other mesenchymal and nonmesenchymal tumor types. These results support the use of DOG1 as a biomarker for GIST.

Anoctamin 1, ANO1 Calcium activated chloride channel Discovered on gastrointestinal stromal tumors protein 1 Oral cancer overexpressed protein 2, ORAOV2 Transmembrane protein 16A, TMEM16A Tumor-amplified and overexpressed sequence 2, TAOS2 Gene name : ANO1

Gene ID: 55107

UniProt: Q5XXA6