PITX2 antibody (AA 1-100)

Catalog No. ABIN3015652

The Rabbit Polyclonal anti-PITX2 antibody has been validated for WB. It is suitable to detect PITX2 in samples from Human.

Quick Overview for PITX2 antibody (AA 1-100) (ABIN3015652)

Target: PITX2 (Paired-Like Homeodomain 2 (PITX2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PITX2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PITX2 Antibody

Binding Specificity: AA 1-100

Sequence: MNCMKGPLHL EHRAAGTKLS AVSSSSCHHP QPLAMASVLA PGQPRSLDSS KHRLEVHTIS DTSSPEAAEK DKSQQGKNED VGAEDPSKKK RQRRQRTHFT

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PITX2 (NP_000316.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PITX2

Target: PITX2 (Paired-Like Homeodomain 2 (PITX2))

Alternative Name: PITX2

Background: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.,PITX2,ARP1,ASGD4,Brx1,IDG2,IGDS,IGDS2,IHG2,IRID2,Otlx2,PTX2,RGS,RIEG,RIEG1,RS,Epigenetics & Nuclear Signaling,Transcription Factors,Cell Biology & Developmental Biology,Cardiovascular,Heart,Cardiogenesis,PITX2

Molecular Weight: 30 kDa/35 kDa

Gene ID: 5308

UniProt: Q99697

Pathways: Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development