ZAP70 antibody (pTyr493)

Catalog No. ABIN3020535

This anti-ZAP70 antibody is a Rabbit Polyclonal antibody detecting ZAP70 in WB, IHC and IF. Suitable for Human.

Quick Overview for ZAP70 antibody (pTyr493) (ABIN3020535)

Target: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZAP70 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ZAP70 Antibody

Binding Specificity: pTyr493

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Phosphorylated Antibodies

Immunogen: A phospho specific peptide corresponding to residues surrounding Y493 of human ZAP70

Isotype: IgG

Application Details

Application Notes: WB,1:2000 - 1:5000,IHC,1:50 - 1:100,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ZAP70

Target: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Alternative Name: ZAP70

Background: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.,ZAP70,ADMIO2,IMD48,SRK,STCD,STD,TZK,ZAP-70,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Immunology & Inflammation,T Cell Receptor Signaling Pathway,Protein phosphorylation,ZAP70

Molecular Weight: 35 kDa/55 kDa/69 kDa

Gene ID: 7535

UniProt: P43403

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway