FGF2 antibody (AA 143-288)

Catalog No. ABIN3020745

Product Details anti-FGF2 Antibody

Target: FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

Binding Specificity: AA 143-288

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: PALPEDGGSG AFPPGHFKDP KRLYCKNGGF FLRIHPDGRV DGVREKSDPH IKLQLQAEER GVVSIKGVCA NRYLAMKEDG RLLASKCVTD ECFFFERLES NNYNTYRSRK YTSWYVALKR TGQYKLGSKT GPGQKAILFL PMSAKS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 143-288 of human FGF2 (NP_001997.5).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-FGF2 antibody (ABIN3020745)

Huang, Zhang, Zhang, Rehman, Tong, Qiu, Jiang, Iqbal, Shahzad, Shen, Li: "Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens." in: Scientific reports, Vol. 8, Issue 1, pp. 3680, (2018) (PubMed).

Target Details for FGF2

Target: FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))

Alternative Name: FGF2 (FGF2 Products)

Background: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.,BFGF,FGF-2,FGFB,HBGF-2,Basic FGF,FGF2,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Neuroscience,Stem Cells,Neural Stem Cells,Cardiovascular,Angiogenesis,Angiogenic growth factors,FGF2

Molecular Weight: 17 kDa/21 kDa/22 kDa/30 kDa

Gene ID: 2247

UniProt: P09038

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, C21-Steroid Hormone Metabolic Process, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Protein targeting to Nucleus, S100 Proteins