HDAC1 antibody (AA 393-482)

Catalog No. ABIN3020754

Product Details anti-HDAC1 Antibody

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Binding Specificity: AA 393-482

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Sequence: SGDEDEDDPD KRISICSSDK RIACEEEFSD SEEEGEGGRK NSSNFKKAKR VKTEDEKEKD PEEKKEVTEE EKTKEEKPEA KGVKEEVKLA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 393-482 of human HDAC1 (NP_004955.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:100 - 1:200,IF,1:50 - 1:100,IP,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-HDAC1 antibody (ABIN3020754)

Fan, Li, Wang, Emerson, Xu: "A Novel ZIP4-HDAC4-VEGFA Axis in High-Grade Serous Ovarian Cancer." in: Cancers, Vol. 13, Issue 15, (2021) (PubMed).

Tao, Hsu, Ma, Cheng, Lee: "Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease." in: Cell death and differentiation, Vol. 24, Issue 4, pp. 597-614, (2018) (PubMed).

Zeng, Huang, Wang, Wu, Wu, Huang: "Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells." in: Neuroscience, Vol. 294, pp. 172-81, (2015) (PubMed).

Target Details for HDAC1

Target: HDAC1 (Histone Deacetylase 1 (HDAC1))

Alternative Name: HDAC1 (HDAC1 Products)

Background: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.,GON-10,HD1,RPD3,RPD3L1,HDAC1,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Deacetylation,Nuclear Receptor Signaling,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,G1/S Checkpoint,Notch Signaling Pathway,Wnt/β-Catenin Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Stem Cells,Cardiovascular,Heart,Hypertrophy,HDAC1

Molecular Weight: 55 kDa

Gene ID: 3065

UniProt: Q13547

Pathways: Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis