CD44 antibody (AA 35-300)

Catalog No. ABIN3021913

The Rabbit Polyclonal anti-CD44 antibody has been validated for WB and IHC. It is suitable to detect CD44 in samples from Human. There is 1 publication available.

Quick Overview for CD44 antibody (AA 35-300) (ABIN3021913)

Target: CD44

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD44 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CD44 Antibody

Binding Specificity: AA 35-300

Sequence: HVEKNGRYSI SRTEAADLCK AFNSTLPTMA QMEKALSIGF ETCRYGFIEG HVVIPRIHPN SICAANNTGV YILTSNTSQY DTYCFNASAP PEEDCTSVTD LPNAFDGPIT ITIVNRDGTR YVQKGEYRTN PEDIYPSNPT DDDVSSGSSS ERSSTSGGYI FYTFSTVHPI PDEDSPWITD STDRIPATST SSNTISAGWE PNEENEDERD RHLSFSGSGI DDDEDFISST ISTTPRAFDH TKQNQDWTQW NPSHSNPEVL LQTTTR

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 35-300 of human CD44 (NP_001001389.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-CD44 antibody (ABIN3021913)

Ji, Yang, Tang, Yang, Tian, Yao, Zhu, Zhang, Ji, Zheng: "Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation." in: Nature communications, Vol. 8, pp. 15308, (2018) (PubMed).

Target Details for CD44

Target: CD44

Alternative Name: CD44

Background: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.,CDW44,CSPG8,ECMR-III,HCELL,HUTCH-I,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,CD44,CD44,Cancer,Tumor immunology,Tumor biomarkers,Immunology & Inflammation,CD markers,Stem Cells,Hematopoietic Progenitors,Mesenchymal Stem Cells,CD44

Molecular Weight: 3 kDa/15 kDa/32-53 kDa/73-81 kDa

Gene ID: 960

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling