LRP1 antibody (AA 20-270)

Catalog No. ABIN3021969

The Rabbit Polyclonal anti-LRP1 antibody has been validated for WB and IHC. It is suitable to detect LRP1 in samples from Human. There is 1 publication available.

Quick Overview for LRP1 antibody (AA 20-270) (ABIN3021969)

Target: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-LRP1 Antibody

Binding Specificity: AA 20-270

Sequence: AIDAPKTCSP KQFACRDQIT CISKGWRCDG ERDCPDGSDE APEICPQSKA QRCQPNEHNC LGTELCVPMS RLCNGVQDCM DGSDEGPHCR ELQGNCSRLG CQHHCVPTLD GPTCYCNSSF QLQADGKTCK DFDECSVYGT CSQLCTNTDG SFICGCVEGY LLQPDNRSCK AKNEPVDRPP VLLIANSQNI LATYLSGAQV STITPTSTRQ TTAMDFSYAN ETVCWVHVGD SAAQTQLKCA RMPGLKGFVD E

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human LRP1 (NP_002323.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:1000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-LRP1 antibody (ABIN3021969)

Kong, Han, Cui, Zhou, Jiang, Zhang, Wang, Wang, Zhang: "MCM2 mediates progesterone-induced endometrial stromal cell proliferation and differentiation in mice." in: Endocrine, Vol. 53, Issue 2, pp. 595-606, (2017) (PubMed).

Target Details for LRP1

Target: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Alternative Name: LRP1

Background: This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.,LRP1,A2MR,APOER,APR,CD91,IGFBP3R,KPA,LRP,LRP1A,TGFBR5,Epigenetics & Nuclear Signaling,RNA Binding,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Microtubules,Wnt/β-Catenin Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Immunology & Inflammation,CD markers,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Cardiovascular,Blood,Serum Proteins,Lipids,LRP1

Molecular Weight: 31 kDa/504 kDa

Gene ID: 4035

UniProt: Q07954

Pathways: Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling