ENOS antibody (AA 1-120)

Catalog No. ABIN3022122

This Rabbit Polyclonal antibody specifically detects ENOS in WB and IF. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for ENOS antibody (AA 1-120) (ABIN3022122)

Target: ENOS (NOS3) (Nitric Oxide Synthase 3 (Endothelial Cell) (NOS3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ENOS antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-ENOS Antibody

Binding Specificity: AA 1-120

Sequence: MGNLKSVAQE PGPPCGLGLG LGLGLCGKQG PATPAPEPSR APASLLPPAP EHSPPSSPLT QPPEGPKFPR VKNWEVGSIT YDTLSAQAQQ DGPCTPRRCL GSLVFPRKLQ GRPSPGPPAP

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human eNOS (NP_000594.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-ENOS antibody (ABIN3022122)

Luo, Dan Wang, Luo, Zhu, Wang, Ning, Li, Ma, Yang, Jin, Huang, Meng, Li: "Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration." in: Redox biology, Vol. 13, pp. 508-521, (2018) (PubMed).

Luo, Wang, Zhu, Wang, You, Ning, Li, Jin, Huang, Hu, Chen, Meng, Li: "Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration." in: Cell death & disease, Vol. 9, Issue 5, pp. 576, (2018) (PubMed).

Target Details for ENOS

Target: ENOS (NOS3) (Nitric Oxide Synthase 3 (Endothelial Cell) (NOS3))

Alternative Name: NOS3

Background: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants.,NOS3,ECNOS,eNOS,Cancer,Signal Transduction,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Endocrine & Metabolism,AMPK Signaling Pathway,Neuroscience,Cardiovascular,Angiogenesis,Blood,Hypoxia,NOS3

Molecular Weight: 67 kDa/68 kDa/133 kDa

Gene ID: 4846

UniProt: P29474

Pathways: ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Response to Molecule of Bacterial Origin, Myometrial Relaxation and Contraction, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling