CST3 antibody

Catalog No. ABIN3022135

This Rabbit Polyclonal antibody specifically detects CST3 in WB and IF. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for CST3 antibody (ABIN3022135)

Target: CST3 (Cystatin C (CST3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CST3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-CST3 Antibody

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of human Cystatin C

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:10 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-CST3 antibody (ABIN3022135)

Zhou, Jiang, Dong, Yan, You, Su, Gong: "The proteins interacting with C-terminal of μ receptor are identified by bacterial two-hybrid system from brain cDNA library in morphine-dependent rats." in: Life sciences, Vol. 143, pp. 156-67, (2016) (PubMed).

Target Details for CST3

Target: CST3 (Cystatin C (CST3))

Alternative Name: CST3

Background: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein.,CST3,ARMD11,HEL-S-2,Cell Biology & Developmental Biology,Apoptosis,Caspases,Neuroscience,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Neurodegenerative Diseases Markers,Stem Cells,Neural Stem Cells,Cardiovascular,CST3

Molecular Weight: 15 kDa

Gene ID: 1471

UniProt: P01034