Muscarinic Acetylcholine Receptor M2 antibody (AA 208-388)

Catalog No. ABIN3022149

The Rabbit Polyclonal anti-Muscarinic Acetylcholine Receptor M2 antibody has been validated for WB. It is suitable to detect Muscarinic Acetylcholine Receptor M2 in samples from Human.

Quick Overview for Muscarinic Acetylcholine Receptor M2 antibody (AA 208-388) (ABIN3022149)

Target: Muscarinic Acetylcholine Receptor M2 (CHRM2) (Cholinergic Receptor, Muscarinic 2 (CHRM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Muscarinic Acetylcholine Receptor M2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Muscarinic Acetylcholine Receptor M2 Antibody

Binding Specificity: AA 208-388

Sequence: HISRASKSRI KKDKKEPVAN QDPVSPSLVQ GRIVKPNNNN MPSSDDGLEH NKIQNGKAPR DPVTENCVQG EEKESSNDST SVSAVASNMR DDEITQDENT VSTSLGHSKD ENSKQTCIRI GTKTPKSDSC TPTNTTVEVV GSSGQNGDEK QNIVARKIVK MTKQPAKKKP PPSREKKVTR T

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 208-388 of human Muscarinic AChR M2 (ACM2) (NP_001006629.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Muscarinic Acetylcholine Receptor M2

Target: Muscarinic Acetylcholine Receptor M2 (CHRM2) (Cholinergic Receptor, Muscarinic 2 (CHRM2))

Alternative Name: CHRM2

Background: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.,CHRM2,HM2,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,CHRM2

Molecular Weight: 51 kDa

Gene ID: 1129

UniProt: P08172