BTRC antibody (AA 50-340)

Catalog No. ABIN6218745

This Rabbit Polyclonal antibody specifically detects BTRC in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for BTRC antibody (AA 50-340) (ABIN6218745)

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTRC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-BTRC Antibody

Binding Specificity: AA 50-340

Sequence: AFQNSSERED CNNGEPPRKI IPEKNSLRQT YNSCARLCLN QETVCLASTA MKTENCVAKT KLANGTSSMI VPKQRKLSAS YEKEKELCVK YFEQWSESDQ VEFVEHLISQ MCHYQHGHIN SYLKPMLQRD FITALPARGL DHIAENILSY LDAKSLCAAE LVCKEWYRVT SDGMLWKKLI ERMVRTDSLW RGLAERRGWG QYLFKNKPPD GNAPPNSFYR ALYPKIIQDI ETIESNWRCG RHSLQRIHCR SETSKGVYCL QYDDQKIVSG LRDNTIKIWD KNTLECKRIL T

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 50-340 of human beta-TrCP/BTRC (NP_378663.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for BTRC

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Alternative Name: BTRC

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.,BTRC,BETA-TRCP,FBW1A,FBXW1,FBXW1A,FWD1,bTrCP,bTrCP1,betaTrCP,Beta-TRCP,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Hedgehog Signaling Pathway,Wnt/β-Catenin Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Neuroscience,BTRC

Molecular Weight: 65 kDa/68 kDa

Gene ID: 8945

UniProt: Q9Y297

Pathways: Cell Division Cycle, Hedgehog Signaling