TLR5 antibody (AA 714-858)

Catalog No. ABIN3022439

This anti-TLR5 antibody is a Rabbit Polyclonal antibody detecting TLR5 in WB and IHC. Suitable for Human.

Quick Overview for TLR5 antibody (AA 714-858) (ABIN3022439)

Target: TLR5 (Toll-Like Receptor 5 (TLR5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TLR5 Antibody

Binding Specificity: AA 714-858

Sequence: HLDTQYSDQN RFNLCFEERD FVPGENRIAN IQDAIWNSRK IVCLVSRHFL RDGWCLEAFS YAQGRCLSDL NSALIMVVVG SLSQYQLMKH QSIRGFVQKQ QYLRWPEDLQ DVGWFLHKLS QQILKKEKEK KKDNNIPLQT VATIS

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 714-858 of human TLR5 (NP_003259.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TLR5

Target: TLR5 (Toll-Like Receptor 5 (TLR5))

Alternative Name: TLR5

Background: This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.,MELIOS,SLE1,SLEB1,TIL3,TLR5,Immunology & Inflammation,Toll-like Receptor Signaling Pathway,Cell Intrinsic Innate Immunity Signaling Pathway,TLR Signaling,TLR5

Molecular Weight: 97 kDa

Gene ID: 7100

UniProt: O60602

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades