Macrophage Scavenger Receptor 1 antibody (AA 192-451)

Catalog No. ABIN3022664

The Rabbit Polyclonal anti-Macrophage Scavenger Receptor 1 antibody has been validated for WB. It is suitable to detect Macrophage Scavenger Receptor 1 in samples from Human.

Quick Overview for Macrophage Scavenger Receptor 1 antibody (AA 192-451) (ABIN3022664)

Target: Macrophage Scavenger Receptor 1 (MSR1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Macrophage Scavenger Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Macrophage Scavenger Receptor 1 Antibody

Binding Specificity: AA 192-451

Sequence: LNIENLNGKI QENTFKQQEE ISKLEERVYN VSAEIMAMKE EQVHLEQEIK GEVKVLNNIT NDLRLKDWEH SQTLRNITLI QGPPGPPGEK GDRGPTGESG PRGFPGPIGP PGLKGDRGAI GFPGSRGLPG YAGRPGNSGP KGQKGEKGSG NTLTPFTKVR LVGGSGPHEG RVEILHSGQW GTICDDRWEV RVGQVVCRSL GYPGVQAVHK AAHFGQGTGP IWLNEVFCFG RESSIEECKI RQWGTRACSH SEDAGVTCTL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 192-451 of human MSR1 (NP_619729.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Macrophage Scavenger Receptor 1

Target: Macrophage Scavenger Receptor 1 (MSR1)

Alternative Name: MSR1

Background: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.,MSR1,CD204,SCARA1,SR-A,SR-AI,SR-AII,SR-AIII,SRA,phSR1,phSR2,Cancer,Endocrine & Metabolism,Lipid Metabolism,Immunology & Inflammation,CD markers,Cell Intrinsic Innate Immunity Signaling Pathway,Cardiovascular,Heart,Cardiovascular diseases,Heart disease,MSR1

Molecular Weight: 39 kDa/42 kDa/49 kDa

Gene ID: 4481

UniProt: P21757