CYP2E1 antibody (AA 234-493)

Catalog No. ABIN3023079

This anti-CYP2E1 antibody is a Rabbit Polyclonal antibody detecting CYP2E1 in WB and IHC. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for CYP2E1 antibody (AA 234-493) (ABIN3023079)

Target: CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP2E1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CYP2E1 Antibody

Binding Specificity: AA 234-493

Sequence: KVIKNVAEVK EYVSERVKEH HQSLDPNCPR DLTDCLLVEM EKEKHSAERL YTMDGITVTV ADLFFAGTET TSTTLRYGLL ILMKYPEIEE KLHEEIDRVI GPSRIPAIKD RQEMPYMDAV VHEIQRFITL VPSNLPHEAT RDTIFRGYLI PKGTVVVPTL DSVLYDNQEF PDPEKFKPEH FLNENGKFKY SDYFKPFSTG KRVCAGEGLA RMELFLLLCA ILQHFNLKPL VDPKDIDLSP IHIGFGCIPP RYKLCVIPRS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 234-493 of human CYP2E1 (NP_000764.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-CYP2E1 antibody (ABIN3023079)

Ma, Zhu, Tan, Mao, Tang, Shen, Zhang, Kuang, Fei, Yang, Wang: "Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway." in: American journal of cancer research, Vol. 7, Issue 3, pp. 433-447, (2017) (PubMed).

Target Details for CYP2E1

Target: CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))

Alternative Name: CYP2E1

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.,CYP2E1,CPE1,CYP2E,P450-J,P450C2E,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Cytochromes,Lipid Metabolism,Cytochromes,Lipases,Drug metabolism,Cardiovascular,Lipids,CYP2E1

Molecular Weight: 56 kDa

Gene ID: 1571

UniProt: P05181