RAPGEF3 antibody (AA 1-200)

Catalog No. ABIN3023196

This Rabbit Polyclonal antibody specifically detects RAPGEF3 in WB. It exhibits reactivity toward Human.

Quick Overview for RAPGEF3 antibody (AA 1-200) (ABIN3023196)

Target: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAPGEF3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RAPGEF3 Antibody

Binding Specificity: AA 1-200

Sequence: MVLRRMHRPR SCSYQLLLEH QRPSCIQGLR WTPLTNSEES LDFSESLEQA STERVLRAGR QLHRHLLATC PNLIRDRKYH LRLYRQCCSG RELVDGILAL GLGVHSRSQV VGICQVLLDE GALCHVKHDW AFQDRDAQFY RFPGPEPEPV GTHEMEEELA EAVALLSQRG PDALLTVALR KPPGQRTDEE LDLIFEELLH

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Epac1/Epac1/RAPGEF3 (NP_001092002.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RAPGEF3

Target: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Alternative Name: RAPGEF3

Background: Guanine nucleotide exchange factor (GEF for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.,RAPGEF3,CAMP-GEFI,EPAC,EPAC1,HSU79275,bcm910,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,MAPK-Erk Signaling Pathway,Endocrine & Metabolism,Immunology & Inflammation,RAPGEF3

Molecular Weight: 66 kDa/99 kDa/103 kDa

Gene ID: 10411

UniProt: O95398

Pathways: cAMP Metabolic Process