DRD3 antibody (Cytoplasmic Domain)

Catalog No. ABIN302336

The Rabbit Polyclonal anti-DRD3 antibody is suitable to detect DRD3 in samples from Human. It has been validated for IHC (p).

Quick Overview for DRD3 antibody (Cytoplasmic Domain) (ABIN302336)

Target: DRD3 (Dopamine Receptor D3 (DRD3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DRD3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-DRD3 Antibody

Binding Specificity: Cytoplasmic Domain

Specificity: This antibody detects Dopamine Receptor D3 (DRD3).

Purification: Immunoaffinity Chromatography.

Immunogen: DRD3 antibody was raised against synthetic peptide from 3rd cytoplasmic domain of human DRD3 / Dopamine Receptor D3.

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections (20 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for DRD3

Target: DRD3 (Dopamine Receptor D3 (DRD3))

Alternative Name: Dopamine D3 Receptor

Background: The DRD3 Dopamine Receptor is expressed in brain regions associated with cognitive, emotional, and endocrine functions. DRD3 mediates the effects of drugs used in the treatment of schizophrenia and Parkinson's disease. DRD3 also binds BP897, a potent inhibitor of drug-craving and cocaine-seeking behaviors. Mutations in DRD3 lead to sodium retention in the kidney, resulting in hypertension and increased locomotor activity in mice. Multiple isoforms of DRD3 are produced by alternative splicing.Synonyms: D(3) Dopamine receptor, D3DR, DRD3, Dopamin receptor D3, ETM1, FET1

Gene ID: 1814

NCBI Accession: NP_000787

UniProt: P35462

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Proton Transport, Negative Regulation of Transporter Activity