TGF-beta antibody

Catalog No. ABIN3023878

This anti-TGF-beta antibody is a Mouse Monoclonal antibody detecting TGF-beta in Neut. Suitable for Human, Mouse, Rat, Cow, Dog, Hamster and Monkey.

Quick Overview for TGF-beta antibody (ABIN3023878)

Target: TGF-beta (TGFb)

Reactivity: Human, Mouse, Rat, Cow, Dog, Hamster, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This TGF-beta antibody is un-conjugated

Application: Neutralization (Neut)

Clone: 1D11-16-8

Product Details anti-TGF-beta Antibody

Characteristics: This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80 % identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.

Purification: Protein G affinity chromatography

Immunogen: Bovine TGF-beta2 protein was used as the immunogen for the TGF-beta antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal dilution of the TGF-beta antibody should be determined by the researcher.\. Functional Activity: Cytokine Neutralization (Order SAF formulation)

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the TGF-beta antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for TGF-beta

Target: TGF-beta (TGFb)

Alternative Name: TGF-beta

Background: This mAb recognizes TGF beta 1, 2 and 3. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80 % identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGFb's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus